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42.2 AMYGDALA PERFUSION IS ASSOCIATED WITH AUDITORY VERBAL HALLUCINATIONS WITH EMOTIONAL CONTENT IN SCHIZOPHRENIA PATIENTS
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Abstract:
BACKGROUND: An auditory verbal hallucination (AVH), is typically defined as a perceptual experience of hearing a voice in the absence of a corresponding external source. AVH are key symptoms of schizophrenia and are a highly prevalent major clinical characteristic that severely handicaps the patients. AVH can cause severe impairment in quality of life and a considerable proportion of patients do not respond to available treatment options. The voices that patients experience hearing are often with emotional content which may differ from individuals hearing voices in the general population. Translational approach suggests that AVH implicate speech perception areas in the left temporal lobe, thereby impairing the perception of and attention to external sounds. It is unknown weather amygdala is implicated in the emotional content of the voices or even may distinguish between AVH with emotional content and without emotional content. Preliminary data suggests that patients with AVH with high emotional content may not respond to transcranial magnet stimulation (TMS). Here, we therefore tested whether resting state perfusion may distinguish in schizophrenia patients with AVH with and without emotional content. To our knowledge, this is the first study to explore resting state perfusion in patients with schizophrenia depending on the content of AVH. METHODS: In total, we included 48 schizophrenia spectrum patients and 40 age and gender matched healthy controls. We assessed AVH with the comprehensive assessment of schizophrenia history and the hallucination change scale as well as imaging on a 3T MRI scanner. AVH were currently present in 33 patients and 18 patients had AVH with emotional content. Patients did not differ in antipsychotic medication or positive symptoms. We compared whole brain perfusion using arterial spin labeling (ASL) over all, and between the groups using one-way ANCOVAs (F-test and T-tests). We applied threshold-free cluster enhancement (TFCE) and a statistical threshold of p < 0.05 family wise error corrected for multiple testing (FWE-corr). RESULTS: We found a group effect (F-test) within the superior temporal gyrus and T-tests revealed that patients with AVH had increased perfusion most prominently within the left superior temporal gyrus compared to heathy controls and patients without AVH. Furthermore, T-tests indicated perfusion within the limbic system to be specific to AVH with emotional content. CONCLUSIONS: The STG has been suggested to play a key role in AVH in patients with schizophrenia. Thus, our results are highly compatible with increased superior temporal perfusion as a marker of AVH. Furthermore, distinguishable associations of rCBF with AVH with and without emotional content point to distinct underlying pathophysiology. Whether this may inform on therapy responds to transcranial magnet stimulation has to be further tested.
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Keyword:
Plenary/Symposia
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URL: https://doi.org/10.1093/schbul/sbz022.174
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455372/
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T177. STRUCTURAL ORGANIZATION OF THE PRAXIS NETWORK PREDICTS GESTURE PRODUCTION: EVIDENCE FROM HEALTHY SUBJECTS AND PATIENTS WITH SCHIZOPHRENIA
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